| Preseason |
| August 15, 1981 |
Green Bay Packers vs. Oakland Raiders |
Milwaukee County Stadium |
| August 15, 1981 |
Los Angeles Rams vs. Dallas Cowboys |
Anaheim Stadium |
| August 15, 1981 |
San Francisco 49ers vs. San Diego Chargers |
Candlestick Park |
| August 22, 1981 |
New York Giants vs. New York Jets |
Giants Stadium |
| August 22, 1981 |
Tampa Bay Buccaneers vs. Houston Oilers |
Tampa Stadium |
| Week 1 |
| September 6, 1981 |
New York Giants vs. Philadelphia Eagles |
Giants Stadium |
| September 7, 1981 |
Cleveland Browns vs. San Diego Chargers |
Cleveland Stadium |
| Week 2 |
| September 13, 1981 |
Baltimore Colts vs. Buffalo Bills |
Memorial Stadium |
| September 13, 1981 |
New Orleans Saints vs. Los Angeles Rams |
Louisiana Superdome |
| September 13, 1981 |
San Francisco 49ers vs. Chicago Bears |
Candlestick Park |
| September 13, 1981 |
Washington Redskins vs. New York Giants |
RFK Stadium |
| Week 3 |
| September 17, 1981 |
Buffalo Bills vs. Philadelphia Eagles |
Rich Stadium |
| September 20, 1981 |
Houston Oilers vs. Miami Dolphins |
Astrodome |
| September 20, 1981 |
Kansas City Chiefs vs. San Diego Chargers |
Arrowhead Stadium |
| Week 4 |
| September 27, 1981 |
Cleveland Browns vs. Atlanta Falcons |
Cleveland Stadium |
| September 27, 1981 |
Pittsburgh Steelers vs. New England Patriots |
Three Rivers Stadium |
| Week 5 |
| October 4, 1981 |
Houston Oilers vs. Cincinnati Bengals |
Astrodome |
| October 4, 1981 |
Oakland Raiders vs. Denver Broncos |
Oakland-Alameda County Coliseum |
| October 4, 1981 |
Washington Redskins vs. San Francisco 49ers |
RFK Stadium |
| October 5, 1981 |
Philadelphia Eagles vs. Atlanta Falcons |
Veterans Stadium |
| Week 6 |
| October 11, 1981 |
Pittsburgh Steelers vs. Cleveland Browns |
Three Rivers Stadium |
| October 11, 1981 |
New York Giants vs. St. Louis Cardinals |
Giants Stadium |
| October 11, 1981 |
San Francisco 49ers vs. Dallas Cowboys |
Candlestick Park |
| October 12, 1981 |
Buffalo Bills vs. Miami Dolphins |
Rich Stadium |
| Week 7 |
| October 18, 1981 |
New England Patriots vs. Houston Oilers |
Schaefer Stadium |
| October 18, 1981 |
Oakland Raiders vs. Tampa Bay Buccaneers |
Oakland-Alameda County Coliseum |
| Week 8 |
| October 25, 1981 |
Cleveland Browns vs. Baltimore Colts |
Cleveland Stadium |
| October 25, 1981 |
Oakland Raiders vs. Kansas City Chiefs |
Oakland-Alameda County Coliseum |
| October 25, 1981 |
Philadelphia Eagles vs. Tampa Bay Buccaneers |
Veterans Stadium |
| October 26, 1981 |
Pittsburgh Steelers vs. Houston Oilers |
Three Rivers Stadium |
| Week 9 |
| November 1, 1981 |
Buffalo Bills vs. Cleveland Browns |
Rich Stadium |
| November 1, 1981 |
Los Angeles Rams vs. Detroit Lions |
Anaheim Stadium |
| November 1, 1981 |
Tampa Bay Buccaneers vs. Chicago Bears |
Tampa Stadium |
| November 1, 1981 |
Washington Redskins vs. St. Louis Cardinals |
RFK Stadium |
| Week 10 |
| November 8, 1981 |
Houston Oilers vs. Oakland Raiders |
Astrodome |
| November 8, 1981 |
St. Louis Cardinals vs. Philadelphia Eagles |
Memorial Stadium">Busch Memorial Stadium |
| Week 11 |
| November 15, 1981 |
Philadelphia Eagles vs. Baltimore Colts |
Veterans Stadium |
| November 15, 1981 |
Tampa Bay Buccaneers vs. Denver Broncos |
Tampa Stadium |
| November 15, 1981 |
Minnesota Vikings vs. New Orleans Saints |
Metropolitan Stadium |
| Week 12 |
| November 22, 1981 |
Oakland Raiders vs. San Diego Chargers |
Oakland-Alameda County Coliseum |
| Week 13 |
| November 26, 1981 |
Dallas Cowboys vs. Chicago Bears |
Texas Stadium |
| November 26, 1981 |
Detroit Lions vs. Kansas City Chiefs |
Pontiac Silverdome |
| Week 14 |
| December 6, 1981 |
Seattle Seahawks vs. New York Jets |
Kingdome |
| Week 15 |
| December 13, 1981 |
Oakland Raiders vs. Chicago Bears |
Oakland-Alameda County Coliseum |
| December 13, 1981 |
Pittsburgh Steelers vs. Cincinnati Bengals |
Three Rivers Stadium |
| December 13, 1981 |
Tampa Bay Buccaneers vs. San Diego Chargers |
Tampa Stadium |
| Week 16 |
| December 19, 1981 |
New York Giants vs. Dallas Cowboys |
Giants Stadium |
| December 20, 1981 |
Chicago Bears vs. Denver Broncos |
Soldier Field |
| December 20, 1981 |
New York Jets vs. Green Bay Packers |
Shea Stadium |
| December 20, 1981 |
Philadelphia Eagles vs. St. Louis Cardinals |
Veterans Stadium |
| Postseason |
| December 27, 1981 |
New York Jets vs. Buffalo Bills |
Shea Stadium |
| January 10, 1982 |
Cincinnati Bengals vs. San Diego Chargers |
Riverfront Stadium |
| January 31, 1982 |
NFL Pro Bowl |
Aloha Stadium |
| Media Guides |
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